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目的 观察氨溴索辅助治疗婴幼儿急性下呼吸道感染 (ALRTI)的临床疗效。方法 ALRTI患儿 2 6 4例 ,随机分为氨溴索治疗观察组和对照组 ,观察两组疗效及临床症状和体征消退时间。结果 两组显效率分别为 78 91%和 6 6 91% ,差异有显著意义 (P =0 0 2 9) ;气促、罗音消退时间分别为 1 89±0 5 9d和 2 11± 0 6 0d、 5 0 7± 1 4 1d和 5 6 2± 1 2 2d ,差异有显著意义 (P =0 0 33、P =0 0 0 3) ;发热、咳嗽消退时间分别为 1 97± 0 6 9d和 2 0 0± 0 5 0d、 5 35± 1 5 3d和 5 5 3± 1 37d ,差异无显著意义 (P=0 831、P =0 4 33)。结论 氨溴索可减轻ALRTI的呼吸道阻塞 ,缓解主要临床症状体征 ,有助于ALR TI炎症渗出的吸收
Objective To observe the clinical efficacy of ambroxol in the treatment of acute lower respiratory tract infection (ALRTI) in infants. Methods A total of 2646 children with ALRTI were randomly divided into ambroxol treatment group and control group. The curative effect, clinical symptoms and signs and symptoms of two groups were observed. Results The effective rates of the two groups were 78 91% and 6 6 91%, respectively, with significant difference (P = 0 0 2 9). The time to relief of breathlessness and rales were 1 89 ± 0 59d and 2 11 ± 0 6, respectively 0d, 5 0 7 ± 1 4 1d and 5 6 2 ± 1 2 2d, the difference was significant (P = 0 0 33, P = 0 0 0 3). The fever and cough subsided time were respectively 1 97 ± 0 6 9d (P = 0 831, P = 0 4 33). There was no significant difference between the two groups (P <0.05). Conclusions Ambroxol can relieve airway obstruction of ALRTI, relieve the symptoms and signs of the main clinical symptoms and contribute to the absorption of inflammatory exudation of ALR TI