目的 :探讨帕金森病中大脑额叶皮质的形态及代谢改变。方法 :大鼠实验组于 6 OHDA毁损后用BIOSPEC47/ 3 0磁共振波谱仪 ( 4 .7T) ,采用点分辨波谱法对双侧额叶皮质行1H MRS检测 ,分析该区N 乙酰天门冬氨酸 /肌酸 (NAA/Cr)和胆碱 /肌酸 (Cho/Cr)比值的变化 ,并用电镜观察该区神经元及突触的形态变化。结果 :实验组大鼠损毁侧额叶皮质NAA/Cr比值显著低于对侧 ,对照组两侧无显著差别 ;Cho/Cr比值在两组的两侧相比均无显著差别。电镜观察显示 :损毁侧额叶皮质的突触数量较对侧减少 ,突触前、后膜和突触小泡结构异常 ,典型突触结构消失 ,树突棘出现大片低电子密度区 ,细胞器消失。结论 :帕金森病大鼠模型损毁侧额叶皮质内存在神经元缺失或突触数量的减少 ,突触结构异常及功能异常。 Objective: To investigate the morphological and metabolic changes of the frontal cortex in Parkinson’s disease. Methods: The rat experimental group was subjected to 1H MRS with BIOSPEC47 / 30 magnetic resonance spectrometer (4.6T) after the destruction of 6-OHDA, and 1H-MRS detection of the bilateral frontal cortex by point-resolved spectroscopy. (NAA / Cr) and choline / creatinine (Cho / Cr) ratios were measured. The morphological changes of neurons and synapses were observed under electron microscope. Results: NAA / Cr ratio in the lesioned frontal cortex of the experimental group was significantly lower than that of the contralateral group, and there was no significant difference in the two sides of the control group. Cho / Cr ratio had no significant difference between the two groups. Electron microscopy showed that the number of synapses in the lesion-side frontal cortex decreased compared with the contralateral side, the synaptic structure of synaptic vesicles and synaptic vesicles were abnormal, the typical synaptic structure disappeared, the dendritic spine had a large area of ​​low electron density, and the organelles disappeared . CONCLUSION: There is neuronal loss or synapse number reduction, synaptic structure abnormalities and dysfunction in the lesioned frontal cortex of Parkinson’s disease rats.