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目的 探讨积极血糖干预对慢性阻塞性肺疾病(COPD)患者预后及胰岛β细胞功能的影响.方法 将2012年1月至2015年1月广州医科大学附属第一医院收治的180例COPD患者按照住院号随机分为观察组、对照组各90例.对照组患者采用常规治疗,观察组在常规治疗的基础上加用积极血糖干预措施.观察两组患者预后及胰岛β细胞功能、血气指标、焦虑自评量表(SAS)评分的变化.结果 积极血糖干预后观察组在预后及胰岛β细胞功能的改善方面明显优于对照组,差异有统计学意义(P<0.05);干预后观察组pH值、PaO2显著高于对照组、PaCO2显著低于对照组,差异有统计学意义(均P<0.05);干预后观察组SAS评分显著低于对照组,差异有统计学意义(均P<0.05).结论 积极血糖干预对COPD患者应用后可有效缓解其预后及胰岛β细胞功能,为临床采取有效的积极血糖干预提供理论依据.“,”Objective To investigate the effect of active blood glucose intervention on prognosis and Islet βcell function of the patients with chronic obstructive pulmonary disease(COPD). Methods 180 patients in our hospital from Jan 2012 to Jan 2015 were divided into the observation group (90 cases) and the control group (90 cases) by random number table method. The control group received routine treatment,and the observation group treated with active blood glucose intervention on the basis of routine treatment. And the prognosis and Islet β cell function,blood gas index,SAS scales were observed. Results After active blood glucose intervention,the observation group was superior to the control group obviously on prognosis and Islet β cell function;the difference was significant (P<0.05). After intervention ,the pH ,and PaO2 value of the observation group were significantly higher than the control group;the PaCO2 value of the observation group was significantly lower than that of the control group(P<0.05);the SAS scales of the observation group were significantly lower than the control group (P<0.05). Conclusion Active blood glucose intervention could effectively alleviate the prognosis and Islet β cell function of patients with COPD ,and provide theoretical basis for the treatment.