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设计合成了基于吲哚酰腙单元的钳形阴离子受体(1),UV-Vis滴定实验表明,它在含1%DMSO的CH3CN溶液中能选择性识别具有重要生物学意义的F-、Ac O-和H2PO4-(结合比均为1∶1且Ka>104L/mol),但对Cl-、Br-、I-、NO3-、N3-、HSO4-和Cl O4-无识别作用。与它相比,端基为苯并呋喃的参照化合物2在同样溶剂中对上述3种阴离子的亲和性减弱,尤其是对H2PO4-。核磁滴定实验表明,受体1中的吲哚环NH和酰胺NH能产生协同效应,从而对阴离子产生了强效键合作用。
Design and synthesis of an anion-based pared-anion acceptor based on indole hydrazone moiety (1). UV-Vis titration experiments showed that it can selectively recognize F-, Ac with important biological significance in CH3CN solution containing 1% DMSO O- and H2PO4- (the binding ratios are both 1: 1 and Ka> 104 L / mol) but do not recognize Cl-, Br-, I-, NO3-, N3-, HSO4- and Cl O4-. In contrast, reference compound 2 with terminal benzofuran reduced its affinity for the three anions in the same solvent, especially for H2PO4-. NMR experiments show that the indole ring NH and amide NH in the acceptor 1 can produce a synergistic effect, thereby generating a strong binding effect on the anion.