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目的：评价三七总皂甙及抗坏血酸防护视网膜光化学损伤的效果。方法：本实验于光照前２４ｈ及光照前立即给大鼠腹腔注射三七总皂甙（１００ｍｇ／ｋｇ）及抗坏血酸（０．５ｇ／ｋｇ），进行光损伤的防护研究。以视网膜光镜形态、外核层厚度及丙二醛含量检测作为评判分析指标。结果：光照后６ｄ及１４ｄ，两用药组的光镜下视网膜形态改变及外核层厚度改变均较对照组轻，用药组视网膜丙二醛含量于光照后６ｈ及６ｄ相同时间点显著低于对照组（Ｐ＜０．０５），但两用药组间无统计学差别（Ｐ＞０．０５）。结论：三七总皂甙具有类似抗坏血酸作用，表现出良好的防护效果。其作用机制是能显著减轻光化学损伤后视网膜脂质过氧化作用
Objective: To evaluate the effect of Panax notoginseng saponins and ascorbic acid on the photochemical damage of retina. Methods: The rats were intraperitoneally injected with Panax notoginseng saponins (100 mg / kg) and ascorbic acid (0.5 g / kg) 24 h before light and light before light exposure. Retina light microscopy morphology, outer nuclear layer thickness and MDA content as a measure of analysis of indicators. Results: After 6 and 14 days of light exposure, the morphological changes of the retina and thickness of the outer nuclear layer in both groups were lighter than those in the control group. The content of malondialdehyde in the retina of the two groups was significantly lower than that of the control at 6h and 6d Group (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion: Panax notoginseng has the similar effect of ascorbic acid and shows good protective effect. Its mechanism of action can significantly reduce retinal lipid peroxidation after photochemical injury