论文部分内容阅读
杀伤细胞免疫球蛋白样受体(KIR)主要表达于自然杀伤(NK)细胞和部分T细胞表面。KIR分子的配体是表达于靶细胞上的某些主要组织相容性复合体Ⅰ(MHC-Ⅰ)类分子,两者可形成配体-受体复合物。MHC-Ⅰ/KIR分子相互识别,通过传导活化或抑制信号调节NK细胞的杀伤功能,在免疫应答过程中,MHC-Ⅰ/KIR分子的相互作用可保护机体抵御各种病原体的侵袭。KIR在自身免疫病中的作用越来越受到重视。
Killer cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and on part of T cell surfaces. Ligands of KIR molecules are some of the major histocompatibility complex class I (MHC-I) molecules expressed on target cells, both of which form ligand-receptor complexes. MHC-I / KIR molecules recognize each other and regulate the cytotoxicity of NK cells by activating or inhibiting signal transduction. The interaction of MHC-I / KIR molecules during the immune response protects the body against various pathogens. The role of KIR in autoimmune diseases is gaining more and more attention.