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早在1893年Rcinbach首先报告1例恶性肿瘤患者外周血嗜酸粒细胞显著增多。嗣后,人们陆续发现许多实体肿瘤不仅可引致高嗜酸粒细胞血症(肿瘤相关性血嗜酸粒细胞增多,简称TABE),而且肿瘤组织内也常常有大量嗜酸粒细胞浸润(肿瘤相关性组织嗜酸粒细胞增多,简称TATE)。多年来学者们对嗜酸粒细胞与恶性肿瘤的关系一直关注不已,在病理生理机制、预后意义等方面做了大量工作。本文拟作一简述。一、嗜酸粒细胞及其抗肿瘤作用嗜酸粒细胞是颗粒白细胞的一种。人类成熟嗜酸粒细胞直径10-15μm,胞浆内约含200个折光性颗粒,可被伊红等酸性染料染成桔黄色。这些颗粒由富含精氨酸的碱性蛋白质组成,包括主要碱性蛋白质(Major Basic Protein,MBP)、阳离子蛋白质(ECP)、过氧化酶(EPO)等。肥大细胞、嗜中性
As early as 1893, Rcinbach first reported a significant increase in peripheral blood eosinophils in 1 malignant tumor. Subsequently, one after another found that many solid tumors not only lead to hypereosinophilic (tumor-associated blood eosinophilia, referred to as TABE), but also often have a large number of tumor tissue eosinophil infiltration (tumor-related Tissue eosinophilia, referred to as TATE). Over the years, scholars have always paid close attention to the relationship between eosinophils and malignant tumors, and have done a great deal of work in pathophysiological mechanisms and prognostic significance. This article is intended to give a brief account. First, eosinophils and their antitumor effect Eosinophils are a kind of granular white blood cells. Mature human eosinophils 10-15μm in diameter, the cytoplasm contains about 200 refraction particles can be eyed red and other acid dyes dyed orange. These particles are composed of arginine-rich basic proteins, including Major Basic Protein (MBP), cationic protein (ECP), peroxidase (EPO) and the like. Mast cells, neutrophilic