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AIM:To investigate the prevention and therapy of fungainfection in patients with severe acute pancreatitis (SAP).METHODS:Seventy patients with SAP admitted from Jan.1998 to Dec.2002 were randomly divided into garlicinprevention group,fluconazole (low dosage) prevention groupand control group.The incidence of fungal infection,the fungalclearance and mortality after treatment were compared.RESULTS:The incidence of fungal infection in garlicingroup and fluconazole group was lower than that in controlgroup (16 % vs30 %,P<0.05 and 9 % vs30 %,P<0.01,respectively).Amphotericin B or therapy-dose fluconazolehad effects on patients with fungal infection in garlicin groupand control group,but had no effects on patients with fungalinfection in fluconzole group.CONCLUSION:Prophylactic dosage of antifungal agents(garlicin or low dosage fluconazole) can reduce the incidenceof fungal infection in patients with SAP.But once fungalinfection occurs,amphotericin B should be used as early aspossible if fluconazole is not effective.
AIM: To investigate the prevention and therapy of fungaining in patients with severe acute pancreatitis (SAP). METHODS: Seventy patients with SAP admitted from Jan. 1998 to Dec. 2002 were randomly divided into garlic inprevention group, fluconazole (low dosage) prevention group and control group. The incidence of fungal infection, the fungalclearance and mortality after treatment were compared .RESULTS: The incidence of fungal infection in garlicingroup and fluconazole group was lower than that in controlgroup (16% vs 30%, P <0.05 and 9% vs 30% P <0.01, respectively). Amphotericin B or therapy-dose fluconazolehad effects on patients with fungal infection in garlicin group and control group, but had no effects on patients with fungalinfection in fluconzole group. CONCLUSION: Prophylactic dosage of antifungal agents (garlicin or low dosage fluconazole) can reduce the incidence of fungal infection in patients with SAP.But once fungalinfection occurs, amphotericin B should be used as early aspossible if flu conazole is not effective.