目的　探讨大学生接种重组酵母乙肝疫苗免疫效果及加强免疫的问题 ,以指导今后乙肝预防工作。方法　 2 0 0 1～ 2 0 0 2年在某医学院校对 1997年后入学的大学生 ,两次分层随机抽样的基础上 ,选择明确知道入学时乙肝疫苗接种史的 4 81名学生 ,进行乙肝HBsAg和抗 HBs检测。 结果　大学生接种疫苗后 ,其抗 HBs的平均应答率为 77.34% ,5年内能维持在较好水平。免疫无应答率为 2 2 .6 6 % ,多次接种可提高其应答率。应答率与年龄有关 ,与性别无明显关系。无应答者是乙肝高危人群 ,极易成为传染源。结论　重组酵母乙肝疫苗具有良好免疫原性和安全性 ,有待进一步提高其高水平抗 HBs应答率和持续时间 ,降低无应答率 Objective To probe into the immunization effect and immunization of college students vaccinated with recombinant yeast hepatitis B to guide future hepatitis B prevention. Methods From 2001 to 2002, on the basis of two random stratified stratified random sampling of college students admitted to post-1997 in a medical school, 4 81 students who knew a definite history of hepatitis B vaccination on admission were selected Hepatitis B HBsAg and anti-HBs test. Results The average response rate of anti-HBs to college students after vaccination was 77.34%, which could be maintained at a good level within 5 years. Immune non-response rate of 22.66%, multiple inoculation can improve their response rate. The response rate is age-related and has no significant relationship with gender. Non-responders are high-risk groups of hepatitis B, easily become a source of infection. Conclusion Recombinant yeast Hepatitis B vaccine has good immunogenicity and safety, and needs to further improve its high level of anti-HBs response rate and duration, reduce non-response rate