人体肿瘤异体移植已有近百年的研究历史,而只是在裸鼠问世的十几年来,这方面的研究才有迅猛发展。裸鼠是遗传突变无胸腺小鼠,缺乏排斥异体组织的能力。将人类肿瘤移植于裸鼠,可为人们提供人体外人类肿瘤整体研究体系,在深入研究人癌生物学特性、宿主与肿瘤的相互作用、肿瘤免疫、癌细胞生物学标志及基因表达,以及人癌实验治疗方面发挥着日益巨大的作用。 Human tumor xenotransplantation has a history of nearly one hundred years. Only in the past decade or more since the advent of the nude mouse, research in this area has seen rapid development. Nude mice are genetically mutated athymic mice that lack the ability to reject allogeneic tissue. Transplanting human tumors into nude mice can provide humans with an in-vitro human tumor overall research system, in-depth study of human cancer biological characteristics, host-tumor interaction, tumor immunity, cancer cell biological markers and gene expression, and human Cancer treatment plays an increasingly important role.