论文部分内容阅读
目的 :探讨幽门螺杆菌 (Helicobacterpylori,Hp)cagA基因及iceA基因的存在情况与胃十二指肠疾病的关系。方法 :用PCR方法检测 174例临床病人胃粘膜活检标本中Hp的cagA基因及iceA基因的存在情况。 结果 :cagA的检出率为 89.7% (15 6 / 174) ,iceA1的检出率为 6 2 .1% (10 8/ 174) ,iceA2的检出率为 32 .2 % (5 6 / 174) ,7例为iceA1和iceA2皆阳性 ,3例未能检测到iceA等位基因型。各疾病组间cagA、iceA1、iceA2的检出率无统计学差异。结论 :cagA基因及iceA基因不能作为本地区Hp毒力增强的标志。
Objective: To investigate the relationship between cagA gene and iceA gene of Helicobacter pylori (Hp) and gastroduodenal diseases. Methods: The cagA gene and iceA gene of Hp in 174 cases of gastric mucosal biopsy specimens were detected by PCR. Results: The detection rate of cagA was 89.7% (15 6/174), the detection rate of iceA1 was 62.1% (108/174), and the detection rate of iceA2 was 32.2% (56/174) ), 7 were positive for iceA1 and iceA2, and 3 failed to detect the iceA allele. There was no significant difference in the detection rates of cagA, iceA1 and iceA2 between the various disease groups. Conclusion: The cagA gene and iceA gene can not be used as a marker of Hp virulence in this region.