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目的:分析医嘱用抗菌药物使用的不合理性及其影响因素,为促进临床合理用药提供参考。方法:选取2013年1月—2015年10月间1 326例住院患者的治疗医嘱,分析医嘱用抗菌药物临床使用和DDDs的合理性。结果:分析显示,用药频率最高的为第3代头孢菌素类药物(26.49%);其次,为第2代头孢菌素类药物(16.89%)和第1代孢菌素类药物(14.87%);各头孢菌素类药物占所有抗菌药物的58.25%;1 326份用药医嘱的患者,经药敏分析结果显示,革兰阳性菌为378株占28.51%,革兰阴性菌948株占71.49%;不合理使用抗菌药物的医嘱为132例次,主要表现在给药途径、给药次数及重复用药。结论:通过分析为临床合理使用抗菌药物提供了有力的技术支持,保证了医嘱的合理和安全用药。
Objective: To analyze the unreasonable use of antibacterials and its influencing factors in order to provide reference for clinical rational use of drugs. Methods: From January 2013 to October 2015, 1 326 cases of inpatients were treated and the rationality of clinical use of antimicrobial agents and DDDs were analyzed. Results: The analysis showed that the third-generation cephalosporins were the most frequently used drugs (26.49%), the second-generation cephalosporins (16.89%) and the first-generation cephalosporins (14.87% ); Each cephalosporin drug accounted for 58.25% of all antibacterial drugs; 1 326 prescription medication patients, the susceptibility analysis showed that 378 strains of Gram-positive bacteria accounted for 28.51%, 948 Gram-negative bacteria accounted for 71.49 %; 132 cases of unreasonable use of antibacterial drugs, mainly in the route of administration, the number of administration and repeated medication. Conclusion: Through the analysis of clinical rational use of antimicrobial drugs provide a strong technical support to ensure that the doctor’s advice of rational and safe medication.