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目的 研究吸入一氧化氮（ＮＯ）对牛肺泡表面活性剂（ＢＰＳ）替代治疗肺灌洗大鼠时疗效的影响。方法 ６４只ＳＤ大鼠经气管导管反复肺灌洗至ＰａＯ２＜ １３．４ｋＰａ和ＰａＣＯ２＞ ８．０ｋＰａ 后，随机分成对照组（组Ⅰ）、ＢＰＳ２５ｍ ｇ／ｋｇ 组（组Ⅱ）、ＢＰＳ５０ｍ ｇ／ｋｇ 组（组Ⅲ）、ＢＰＳ１００ｍ ｇ／ｋｇ 组（组Ⅳ），各组分ａ、ｂ 两亚组，未吸ＮＯ为ａ，ＮＯ吸入为ｂ。观察用药后ＰａＯ２ 、ＰａＣＯ２、肺压力－容量环及肺实质密度变化。结果 单用ＮＯ治疗组（组Ⅰｂ）在ＮＯ＝ ４０ｐｐｍ 时其ＰａＯ２ 较组Ⅰａ 显著升高。单用ＢＰＳ治疗组（组Ⅱａ、组Ⅲａ、组Ⅳａ）其ＰａＯ２ 升幅及ＰａＣＯ２ 降幅均在用药后１５ 分钟内达高峰。ＢＰＳ复合ＮＯ（组Ⅱｂ、组Ⅲｂ、组Ⅳｂ）后，仅组Ⅱｂ、组Ⅲｂ 的ＰａＯ２ 均较单用ＢＰＳ组有进一步的显著上升，但ＰａＣＯ２ 的下降不明显。而组Ⅳｂ 的ＰａＯ２ 、ＰａＣＯ２ 均无明显变化。ＢＰＳ治疗后吸入５ｐｐｍ ＮＯ即能显著改善氧合，吸入ＮＯ浓度进一步升高并不能进一步改善氧合作用。ＢＰＳ复合吸入ＮＯ后，肺顺应性较未吸入前有所降低，但无显著性差异。结论 吸入ＮＯ加强ＢＰＳ替代治疗效果，减少ＢＰＳ用量。吸入ＮＯ ?
Objective To study the effects of inhaled nitric oxide (NO) on the therapeutic effect of bovine alveolar surfactant (BPS) in lung lavage in rats. Methods Sixty-four Sprague-Dawley rats were randomly divided into control group (group Ⅰ), BPS group (25 mg / kg), BPS group (50 mg / kg) (Group Ⅲ), BPS100m g / kg group (group Ⅳ), each component a, b two subgroups, did not take NO as a, NO inhaled as b. PaO2, PaCO2, pulmonary pressure-volume ring and pulmonary parenchymal density were observed after treatment. Results Compared with group Ⅰa, the PaO2 of NO treated group (group Ⅰb) was significantly increased at NO = 40ppm. The PaO2 and PaCO2 decrease in BPS alone group (group IIa, group Ⅲa, group Ⅳa) all reached the peak within 15 minutes after treatment. After treated with BPS alone (group IIb, group Ⅲb, group Ⅳb), the PaO2 of group Ⅱb and group Ⅲb increased more than that of group BPS alone, but the decrease of PaCO2 was not obvious. However, PaO2 and PaCO2 in group Ⅳb did not change significantly. BPS inhalation of 5ppm NO can significantly improve oxygenation, inhalation of NO concentration further increased and can not further improve the oxygenation. BPS inhalation of NO, pulmonary compliance than before inhalation was reduced, but no significant difference. Conclusions Inhaled NO enhances the effectiveness of BPS replacement therapy and reduces the dosage of BPS. Inhalation of NO?