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目的评价小剂量多巴胺治疗新生儿窒息后肾损害的疗效。方法选取我院在2010年1月到2012年7月收治的97例窒息新生儿,将其随机分为治疗组和对照组,治疗组49例患儿在进行临床常规对症治疗的基础上给予患儿小剂量多巴胺进行治疗,对照组48例患者则只进行临床常规对症治疗,对比两组患儿的临床效果以及各脏器的损伤情况。结果治疗组患儿有效率为97.96%;对照组患儿有效率为72.92%,两组患儿在临床治疗效果方面对比,治疗组明显优于对照组患儿,差异具有统计学意义(P<0.05)。治疗组患儿在心功能损害和HIE方面差异无统计学意义(P>0.05),肾功能损害和胃肠功能障碍方面,治疗组明显低于对照组患儿,对比差异有统计学意义(P<0.01)。结论窒息新生儿采用小剂量多巴胺治疗不仅可以提高治疗效果,且能够降低胃肠、肾脏等脏器的损伤程度,使病程缩短,最大限度的缓解患儿的病情,减轻患儿痛苦,降低家庭就医费用,具有显著的临床价值。
Objective To evaluate the efficacy of low-dose dopamine in the treatment of nephropathy after neonatal asphyxia. Methods 97 neonates with asphyxia admitted in our hospital from January 2010 to July 2012 were selected and randomly divided into treatment group and control group. 49 children in treatment group were given routine clinical symptomatic treatment Small doses of dopamine for treatment, 48 patients in the control group were only routine clinical symptomatic treatment, compared the clinical effects of both groups of children and the damage of various organs. Results The effective rate was 97.96% in the treatment group and 72.92% in the control group. The clinical efficacy of the two groups was better than that of the control group, the difference was statistically significant (P < 0.05). There was no significant difference between the treatment group and the control group in terms of cardiac dysfunction and HIE (P> 0.05), renal dysfunction and gastrointestinal dysfunction, the difference was statistically significant (P < 0.01). Conclusion Asphyxial neonatal small dose of dopamine treatment can not only improve the therapeutic effect, but also reduce the damage of gastrointestinal, kidney and other organs, shorten the course of disease, maximally alleviate the condition of children, reduce the suffering of children and reduce the family medical treatment Costs, with significant clinical value.