甲氧氯普胺是最常用的止吐药物之一,5-羟色胺受体阻滞剂出现以前,高剂量甲氧氯普胺常用于防治抗癌药所致的恶心呕吐[1,2]。目前,临床上还常用甲氧氯普胺与5-羟色胺受体阻滞剂联合应用,治疗化疗药物所引起的重度恶心、呕吐[3,4],但是甲氧氯普胺有许多不良反应,如昏睡、烦躁不安 Metoclopramide is one of the most commonly used antiemetic drugs, high-dose metoclopramide commonly used in the prevention and treatment of nausea and vomiting caused by anticancer drugs before the advent of serotonin receptor blockers [1,2]. At present, the clinical application of metoclopramide and serotonin receptor blocker is also commonly used in the treatment of severe nausea and vomiting caused by chemotherapy drugs [3,4], but metoclopramide has many adverse reactions, Such as drowsiness, irritability