胎儿出生后,呼吸的启动和从胎儿型肺循环转换过渡到新生儿型肺循环是一个重要的关键时刻,过渡的失败可引起以新生儿持续性肺动脉高压(PPHN)为代表的一系列病理生理学变化。胎儿和新生儿的血管张力是通过血管收缩和扩张之间的平衡来维持的,包括机械因素和内源性血管活性介质等。 After the birth of the fetus, the initiation of respiration and the transition from fetal pulmonary circulation to the neonatal pulmonary circulation are an important pivotal moment. The failure of transition can cause a series of pathophysiological changes represented by neonatal persistent pulmonary hypertension (PPHN). Vascular tension in the fetus and newborn is maintained through the balance between vasoconstriction and expansion, including mechanical factors and endogenous vasoactive mediators.