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为了寻找新的具有亲心肌性质的９９ｍＴｃＮ药物，合成了一种新的Ｎ２Ｓ２配体：Ｎ，Ｎ’－二（２－巯基丙基）－１，２－苯二胺（ＢＭＰＢＤＡ）。以ＳｎＣｌ２为还原剂， Ｈ２ＮＮＨ－（Ｃ＝Ｓ）－ＳＣＨ３为Ｎ３－给予体，通过交换反应制备了放化纯大于９０％的９９ｍＴｃＮ－ＢＭＰＢＤＡ。探讨了ｐＨ值对９９ｍＴｃＮ－ＢＭＰＢＤＡ放化纯的影响，并对其小鼠生物分布进行了研究。结果表明，９９ｍＴｃＮ－ＢＭＰＢＤＡ在心肌中具有较高的初始摄取，静脉注射后２ｍｉｎ时的心肌摄取为２４．５３％ＩＤ·ｇ－１。但心肌清除稍快，注射后３０ｍｉｎ时的心肌摄取为７．９７％ＩＤ·ｇ－１。血清除较快，血半清除期小于１５ｍｉｎ，但血液中活性较高。本工作对于设计新的９９ｍＴｃＮ心肌显像剂具有参考价值。
In order to find new 99mTcN drug with cardiac muscle properties, a novel N2S2 ligand was synthesized: N, N’-bis (2-mercaptopropyl) -1,2-phenylenediamine (BMPBDA). Using SnCl2 as reductant and H2NNH- (C = S) -SCH3 as the N3-donor, 99mTcN-BMPBDA with more than 90% pure radioactivity was prepared by the exchange reaction. The effect of pH value on the radiochemical purity of 99mTcN-BMPBDA was investigated. The biodistribution of the 99mTcN-BMPBDA was studied. The results showed that 99mTcN-BMPBDA had a higher initial uptake in myocardium, and myocardial uptake was 24.53% ID · g-1 at 2 min after intravenous injection. However, myocardial clearance was slightly faster and myocardial uptake was 7.97% ID · g-1 at 30 min after injection. Serum in addition to faster, half-blood clearance less than 15min, but higher blood activity. This work for the design of a new 99mTcN myocardial imaging agent has a reference value.