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目的探讨口服小剂量糖皮质激素及孟鲁斯特联合妥洛特罗贴剂在婴幼儿反复喘息发作急性期中的治疗疗效。方法我院2011年4月至2014年3月儿科门诊收治的163名婴幼儿反复喘息发作急性期患儿,将所有患儿随机分为联合治疗组及常规治疗组,常规治疗组予抗感染、氧疗、纠正酸解平衡及电解质紊乱等治疗,联合治疗组在常规治疗的基础上予口服小剂量糖皮质激素及孟鲁斯特联合妥洛特罗贴剂。采用t检验比较两组的临床症状评分及治疗方案接受度。结果同常规治疗组相比,治疗3d及7d的临床症状评分分别为2.56分、0.75分,明显低于对照组的5.44分、2.07分;而通过统计两组患儿家属对治疗方案的接受度,联合治疗方案的接受度更高。结论在常规治疗基础上加用口服小剂量糖皮质激素及孟鲁斯特联合妥洛特罗贴剂可用于婴幼儿反复喘息发作急性期的治疗,能够促进肺部啰音消失,缩短病程,且易被患儿家属接受。
Objective To investigate the curative effect of oral small dose of glucocorticoid and Montelukast combined with tulobuterol in the acute stage of recurrent wheezing in infants. Methods From April 2011 to March 2014, 163 infants and young children admitted to our Pediatric Outpatient Hospital received repeated episodes of wheezing and acute respiratory failure. All children were randomly divided into combined treatment group and conventional treatment group. Conventional treatment group was given anti-infection, Oxygen therapy, correct acid-base balance and electrolytes disorders and other treatment, the combination therapy group on the basis of conventional treatment to oral low-dose glucocorticoid and montelukast combined with tulobuterol patch. The t-test was used to compare clinical symptom scores and treatment regimens. Results Compared with the conventional treatment group, the scores of clinical symptoms on the 3rd and 7th day of treatment were 2.56 points and 0.75 points, respectively, which were significantly lower than those of the control group (5.44 and 2.07 points respectively) , The acceptance of the combination therapy is higher. Conclusion The combination of oral low-dose glucocorticoid and Montelukast combined with tulobuterol can be used in the treatment of acute recurrent wheezing in infants and young children, which can promote the disappearance of pulmonary rales and shorten the course of disease Easily be accepted by children’s families.