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Resilience is the psychological capability to recover from difficulties quickly.Healthcare professionals are especially vulnerable to job-related stress and burnout.Unitary Caring Science is the framework for Watson’s Human Caring Theory,providing a philosophy of practice in healthcare.With the high rates of clinician burnout and psychological issues,it will be significant to unify the human caring theory with research-informed psychological and neuroscience evidence to develop clinicians’resilience-building strategies.The purpose of this article is to introduce a Unitary Caring Science Resilience Model and explain the science behind the core strategies based on Unitary Caring Science philosophy and the psychological and neuroscience research.This model includes six strategies:Embracing loving-kindness for self and others;Nurturing interpersonal and intersubjective connections/relations;Deepening a cre-ative use of self and sense of belonging;Balancing self-learning,self-awareness,and an evolved self-consciousness;Valuing forgiveness and releasing negativity;Inspiring and maintaining faith-hope.The caring-theory guided resilience-building strategies are proven to alleviate the depletion of clinicians’energy and emotions.Healthcare practices are challenging but rewarding.Clinicians can be emotionally,psychologically,and physically exhausted if they always consider themselves’giving’and’doing’insti-tutional tasks without a sense of purpose or fulfillment.The practice can be rewarding if it becomes more aligned with clinicians’value to serve humanity.Through the unitary caring science resilience strategies,clinicians can build resilience as an antidote to clinician burnout and depletion.