急性淋巴细胞性白血病(acute lymphatic leukemia,ALL)是一种常见的血液系统恶性肿瘤,发病率和病死率均较高,严重危害人群(尤其是青少年)的身心健康[1-2]。绝大多数ALL的病因及发病机制尚未完全清楚,目前,普遍认为是遗传因素与环境因素相互作用的结果。而遗传因素中,融合基因的发生被认为是最主要的危险因素之一。早在1960年,Nowwell和Hungerford在7 Acute lymphoblastic leukemia (ALL) is a common hematological malignancy with high morbidity and mortality, which seriously endangers the health of the population, especially adolescents [1-2]. The etiology and pathogenesis of the vast majority of ALL is not yet fully understood, at present, generally considered to be the result of interaction between genetic and environmental factors. Among genetic factors, the occurrence of fusion gene is considered as one of the most important risk factors. As early as 1960, Nowwell and Hungerford were at seven