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将携带编码乙型肝炎病毒(HBV)表面抗原主要蛋白的S基因的质粒,直接注射小鼠肌肉中,小鼠4周后产生抗-HBs,阳转率83.3%(5/6),加强组阳转率66.7%(2/3),未加强组阳转率为100%(3/3);两组小鼠抗体持续时间可达28周以上;4周以后小鼠体内未检测到HBsAg.
The plasmid carrying the S gene coding for the major protein of hepatitis B virus surface antigen was directly injected into the muscle of mice. Anti-HBs were produced in mice after 4 weeks, the positive conversion rate was 83.3% (5/6) Positive conversion rate was 66.7% (2/3) in the control group, and positive conversion rate was 100% (3/3) in the non-strengthened group. The antibody duration of the two groups was more than 28 weeks. No HBsAg was detected in the mice after 4 weeks.