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目的:探讨奥美拉唑三联疗法在消化性溃疡患者临床症状的影响。方法:选取于2012年9月至2014年9月在我院门诊接受治疗的80例消化性溃疡的患者为研究对象,按照治疗方法的不同分为观察组50例和对照组30例,观察组采用奥美拉唑、阿莫西林、克拉霉素三联疗法,对照组采用雷贝拉唑三联疗效,比较两组的治疗效果、临床症状的变化、不良反应以及治疗成本。结果:观察组与对照组的总有效率分别为88.0%、93.3%,不良反应分别32.0%、26.7%,两组均无统计学意义(P>0.05)。观察组治疗后的症状积分为5.5±1.4,对照组为4.7±1.2,两组之间的无统计学意义(P>0.05)。但观察组的治疗成本低于对照组,有统计学意义(P<0.05)。结论:奥美拉唑三联疗法治疗消化性溃疡疗效好,能明显改善患者的症状,且成本低,值得推广。
Objective: To investigate the effect of omeprazole triple therapy on clinical symptoms in patients with peptic ulcer. Methods: 80 patients with peptic ulcer treated in our hospital from September 2012 to September 2014 were selected as study subjects. According to the different treatment methods, 50 cases in observation group and 30 cases in control group were selected as observation group Using omeprazole, amoxicillin, clarithromycin triple therapy, the control group with rabeprazole triple effect, the two groups were compared the treatment effect, clinical symptoms, adverse reactions and treatment costs. Results: The total effective rate of the observation group and the control group were 88.0% and 93.3% respectively, with adverse reactions of 32.0% and 26.7% respectively. There was no significant difference between the two groups (P> 0.05). Symptom score of observation group after treatment was 5.5 ± 1.4, while that of control group was 4.7 ± 1.2. There was no significant difference between the two groups (P> 0.05). However, the treatment group cost less than the control group, with statistical significance (P <0.05). Conclusion: Omeprazole triple therapy is effective in treating peptic ulcer and can significantly improve the symptoms of patients with low cost, which is worth promoting.