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目的:探讨自身免疫抗体和淋巴细胞因子在习惯性流产(RSA)发病机制中的表达及临床诊断价值。方法:采用ELISA法检测在钦州市妇幼保健院就诊的73例RSA患者和50例非RSA健康体检育龄妇女血清中的免疫抗体和淋巴细胞因子水平,并进行比较分析。结果:RSA患者免疫抗体和Th1细胞因子的阳性率明显升高,与对照组比较差异有统计学意义(P<0.05);随着流产次数的增加,抗精子抗体(ASA)和抗卵巢抗体(AOA)阳性率逐渐降低,抗心磷脂抗体(ACA)、TNF-α和TNF-β阳性率则逐渐升高。结论:RSA患者自身免疫抗体及淋巴细胞Th1型细胞因子水平明显升高,检测这些抗体和细胞因子对临床诊断和治疗RSA具有重要的指导意义。
Objective: To investigate the expression and clinical diagnostic value of autoimmune antibodies and lymphokines in the pathogenesis of habitual abortion (RSA). Methods: The serum levels of immune antibody and lymphocyte factor in 73 cases of RSA patients and 50 cases of non-RSA healthy women of childbearing age treated in Qinzhou Maternal and Child Health Hospital were detected by ELISA and compared. Results: The positive rates of immune antibody and Th1 cytokine in patients with RSA were significantly higher than those in control group (P <0.05). With the increase of the number of abortion, anti-sperm antibody (ASA) and anti-ovarian antibodies AOA) positive rate gradually decreased, anti-cardiolipin antibodies (ACA), TNF-α and TNF-β positive rate was gradually increased. Conclusion: The level of Th1 cytokines in autoimmune antibodies and lymphocytes in patients with RSA is significantly increased. Detection of these antibodies and cytokines is of great guiding significance in the clinical diagnosis and treatment of RSA.