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目的评估与丙型肝炎病毒(HCV)单感染、人免疫缺陷病毒(HIV)单感染相比,HCV/HIV合并感染者体内血清锌的含量变化及意义。方法采用原子吸收分光光度法检测并比较河南某村HCV单感染(129人)、HIV单感染(66人)、HCV/HIV合并感染者(98人)和健康对照者(84人)血清中微量元素锌的含量变化。结果 HCV单感染者、HIV单感染者、HCV/HIV合并感染者和健康对照者血清锌的含量分别为(12.33±1.87)、(11.85±2.79)、(11.70±2.04)、(12.93±2.03)?mol/L。与健康对照者相比,HCV/HIV合并感染者、HCV单感染者、HIV单感染者血清锌的含量均显著降低。HCV/HIV合并感染者与HCV单感染者血清锌相比明显降低。在HCV单感染且ALT≥40(IU/L)者中白蛋白与血清锌呈正相关(r=0.3593,P=0.0052)。在HCV/HIV感染者和HIV感染者中CD4+T细胞数低者(<500/?l)血清锌含量分别为(10.72±1.78)、(10.91±2.27)?mol/L,CD4+T细胞数高者(≥500/?l)血清锌含量分别为(12.01±1.67)、(12.36±2.52)μmol/L。HIV阳性者中,无论HCV合并感染与否,与免疫正常者相比,免疫受损者血清锌含量均明显降低。结论 HCV单感染、HIV单感染均可使血清锌降低,HCV/HIV合并感染加重了锌的缺乏,在HCV单感染且ALT≥40(IU/L)者中血清锌的水平和白蛋白呈正相关,在HCV/HIV合并感染和HIV单感染者血清锌的变化和免疫受损水平有关。[营养学报,2014,36(1):40-44]
Objective To evaluate the changes and significance of serum zinc in HCV / HIV co-infected patients with hepatitis C virus (HCV) single infection and human immunodeficiency virus (HIV) single infection. Methods Atomic absorption spectrophotometry was used to detect and compare the levels of trace elements in the serum of single HCV infection (129), single HIV infection (66), HCV / HIV infection (98) and healthy controls (84) Elemental zinc content changes. Results The levels of serum zinc in patients with HCV infection, HIV infection alone, HCV / HIV infection and healthy controls were (12.33 ± 1.87), (11.85 ± 2.79), (11.70 ± 2.04), (12.93 ± 2.03) ? mol / L. Serum zinc levels were significantly lower in HCV / HIV co-infected, HCV co-infected and HIV co-infected individuals than in healthy controls. HCV / HIV co-infected patients were significantly lower than serum zinc in patients with HCV infection alone. Albumin was positively correlated with serum zinc in patients with single HCV infection and ALT≥40 (IU / L) (r = 0.3593, P = 0.0052). The levels of serum zinc in patients with low CD4 + T cell count (<500 /? L) were (10.72 ± 1.78) and (10.91 ± 2.27)? Mol / L in HCV / The highest serum zinc levels (≥500 /? L) were (12.01 ± 1.67) and (12.36 ± 2.52) μmol / L, respectively. Among HIV-positive persons, serum zinc levels in immunocompromised patients were significantly lower than those in immunocompetent patients irrespective of HCV coinfection. Conclusions Single serum of HCV and single HIV infection can reduce serum zinc and the combined infection of HCV / HIV aggravates the deficiency of zinc. Serum zinc and albumin are positively correlated with single HCV infection and ALT≥40 (IU / L) , In HCV / HIV co-infection and HIV single infection serum zinc levels and immune damage related. [Journal of Nutrition, 2014,36 (1): 40-44]