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目的:研究COX-2在喉鳞状细胞癌中的表达,探讨其与喉癌的生长、浸润及转移的关系。方法:应用半定量RT-PCR方法对标本中COX-2 mRNA的表达进行检测,应用免疫组织化学方法对标本中COX-2蛋白的表达进行检测,并对COX-2的表达情况与疾病生物学特点的关系进行研究。结果:COX-2 mRNA及蛋白在喉鳞状细胞癌组织中高表达,与在声带息肉组织中的表达差异有统计学意义(P<0.01),且随肿瘤的进展COX-2的表达强度增加。结论:COX-2是较为有效的生物学指标,指示喉鳞状细胞癌的发生和发展。同时应用RT-PCR方法及免疫组织化学方法检测喉癌标本,既保证了灵敏度又兼顾了特异度。
Objective: To investigate the expression of COX-2 in laryngeal squamous cell carcinoma and its relationship with the growth, invasion and metastasis of laryngeal carcinoma. Methods: The expression of COX-2 mRNA was detected by semi-quantitative RT-PCR. The expression of COX-2 protein in samples was detected by immunohistochemical method. The expression of COX-2 was correlated with disease biology Characteristics of the relationship between the study. Results: The expression of COX-2 mRNA and protein in laryngeal squamous cell carcinoma was significantly higher than that in vocal cord polyps (P <0.01), and the expression of COX-2 increased with tumor progression. Conclusion: COX-2 is a more effective biological indicator of the occurrence and development of laryngeal squamous cell carcinoma. At the same time, RT-PCR and immunohistochemistry were used to detect laryngeal cancer specimens, which not only ensured the sensitivity but also the specificity.