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三七皂苷(PNS)是五加科人参属植物三七的主要有效活性成分,含有多种单体皂苷。近年来,随着三七在临床的广泛应用,其改善缺血微环境的作用,引起了研究者的关注。该文概述了PNS调节血管、保护血管内皮细胞、消除水肿、抑制氧化应激、抑制凋亡、影响血液流变学、调节免疫等作用机制,为PNS改善实验性脑异常微环境及机制研究提供依据和新的思路,为相关研究提供参考。
Panax notoginsenoside (PNS) is the main active component of Panax notoginseng from Panax notoginseng and contains a variety of monomeric saponins. In recent years, with the wide application of Panax notoginseng in clinical practice, its role in improving ischemic microenvironment has drawn the attention of researchers. This paper summarizes the mechanism of action of PNS in improving experimental microenvironment and mechanism of experimental brain abnormalities by regulating blood vessels, protecting vascular endothelial cells, eliminating edema, inhibiting oxidative stress, inhibiting apoptosis, affecting hemorrheology and regulating immunity. Based on and new ideas for the relevant research provide a reference.