红霉素是在50年代发现的第一个大环内酯类抗生素,在临床使用上受到患者的欢迎,但是红霉素的抗菌谱窄,而且容易被胃酸破坏,每天需要服用4次,这些不足之处也使它在使用方面受到了一定的影响,随着化学制药技术的进步,药学研究者发现通过对其进行化学改造可以克服上述的缺点,在80年代末期到90年代初期红霉素家族相继出现了三个新成员,这些药物的抗 Erythromycin is the first macrolide antibiotic discovered in the 1950s and has been well received by patients for clinical use. However, erythromycin has a narrow antibacterial spectrum and is easily destroyed by gastric acid and needs to be taken 4 times a day Shortcomings also make it in use has been affected, with the progress of chemical technology, pharmaceutical researchers found that by chemical modification can overcome the above shortcomings in the late 80s to early 90s erythromycin There have been three new members of the family, the resistance of these drugs