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目的:观察抑亢汤对多囊卵巢综合征(PCOS)的干预作用。方法:对青春期前雌性大鼠持续皮下注射睾酮(T)及hCG制作PCOS大鼠模型,分别给予抑亢汤(抑亢汤组)、螺内酯(螺内酯组)、生理盐水(对照组、PCOSI组、PCOSII组)治疗6周。结果:抑亢汤组大鼠血清T明显下降(P<0.05),体重明显减轻(P<0.05),囊性卵泡数量减少,黄体数量增多。螺内酯组大鼠的血清T(P>0.05)、体重(P>0.05)与PCOSI组相比均未见明显差异。结论:“T+hCG”诱导的PCOS动物模型适用于观察具有短期疗效的药物,抑亢汤治疗PCOS疗效确切并且能在短期内显效。
Objective: To observe the inhibitory effect of Yu Kang Decoction on polycystic ovary syndrome (PCOS). Methods: PCOS rat models were established by subcutaneous injection of testosterone (T) and hCG in pre-adolescent female rats. The rats were given PCDT (control group), NS group (control group), spironolactone group PCOSII group) for 6 weeks. Results: The serum T was significantly decreased in YKK group (P <0.05), the body weight was significantly reduced (P <0.05), the number of cystic follicles was decreased and the number of corpus luteum was increased. Serum T (P> 0.05) and body weight (P> 0.05) of spironolactone group had no significant difference compared with PCOSI group. CONCLUSION: The animal model of PCOS induced by “T + hCG” is suitable for the observation of drugs with short-term curative effect. Suppository Tang is effective in treating PCOS and can be effective in a short period of time.