The aim of this study was to investigate the clinical characteristics of neonates bo to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19.Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29,2020.Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19.We prospectively collected and analyzed data of mothers and infants.There are 19 neonates included in the research.Among them,10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab,and 9 mothers were clinically diagnosed with COVID-19.Delivery occurred in an isolation room and neonates were immediately separated from the mothers and isolated for at least 14 days.No fetal distress was found.Gestational age of the neonates was 38.6 ± 1.5 weeks,and average birthweight was 3293 ± 425 g.SARS-CoV-2 RT-PCR in throat swab,urine,and feces of all neonates were negative.SARS-CoV-2 RT-PCR in breast milk and amniotic fluid was negative too.None of the neonates developed clinical,radiologic,hematologic,or biochemical evidence of COVID-19.No vertical transmission of SARS-CoV-2 and no perinatal complications in the third trimester were found in our study.The delivery should occur in isolation and neonates should be separated from the infected mothers and care givers.