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目的研究红花黄素对大鼠局灶性脑缺血再灌注损伤(I/R)的保护作用。方法采用线栓法制作大鼠大脑中动脉缺血再灌注模型。插入栓线前、插入栓线0.5 h后以及再灌注2 h后分别监测肛温、肢体Ⅱ导联心电、股动脉压以及大脑局部脑血流量。大鼠清醒后,进行行为学评分,测定脑含水量并进行组织病理学检查。结果 红花黄素能显著提高缺血再灌注后局部脑血流量,对抗血压与心率变化,降低脑组织含水量,缩小脑梗死面积,减轻缺血所致组织病理改变。结论 红花黄素可以增加I/R脑血流量,恢复因缺血造成的自主神经功能损伤,对大鼠局灶性脑缺血再灌注损伤具有保护作用。
Objective To study the protective effect of safflor yellow on focal cerebral ischemia-reperfusion injury (I / R) in rats. Methods The rat middle cerebral artery occlusion (MCAO) model was established by thread occlusion. Rectal temperature, limb II lead ECG, femoral artery pressure, and cerebral regional cerebral blood flow were monitored before plug insertion, 0.5 h after plug insertion and 2 h after reperfusion. After awake, behavioral score, brain water content and histopathological examination were measured. Results safflower yellow can significantly increase the local cerebral blood flow after ischemia-reperfusion, anti-blood pressure and heart rate changes, reduce brain water content, reduce infarct size, reduce ischemia-induced histopathological changes. Conclusion Safflower can increase I / R cerebral blood flow, restore autonomic nerve injury caused by ischemia, and protect cerebral ischemia-reperfusion injury in rats.