环氧合酶是前列腺素合成的限速酶,它被认为与很多炎症、肿瘤的发生有关。目前研究表明,环氧合酶能干扰肝脏脂代谢,使脂代谢异常、甘油三酯蓄积,进而导致肝细胞脂肪变性及炎症。此文就脂肪性肝炎中环氧合酶的影响因素及其作用机理作一综述。 Cyclooxygenase is a rate-limiting enzyme in prostaglandin synthesis and is thought to be involved in many inflammatory and oncogenic events. Current research shows that cyclooxygenase can interfere with liver lipid metabolism, abnormal lipid metabolism, triglyceride accumulation, which in turn lead to fatty degeneration and inflammation of liver cells. This article summarizes the influencing factors of cyclooxygenase in steatohepatitis and its mechanism of action.