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给大鼠侧脑室内注射（ｉｃｖ）硝普钠（ＳＮＰ）、ＮＯ的前体物质Ｌ精氨酸（ＬＡｒｇ）和精精二肽（ＡｒｇＡｒｇ），ＮＯ合成酶（ＮＯＳ）抑制剂ＮＧ硝基Ｌ精氨酸（ＮＮＬＡ），观察清醒状态大鼠血压和心率的变化，探讨脑内ＮＯ对清醒状态大鼠心血管活动的调节作用。实验结果表明，ｉｃｖＳＮＰ（８，１６，３２μｇ）使血压升高，并呈剂量效应关系，同时使心率加快。ｉｃｖＬＡｒｇ（２００μｇ）或不同剂量的精精二肽也使血压升高，心率加快；ｉｃｖＮＮＬＡ（１００μｇ）则使血压下降，心率减慢。以上结果提示，在一定范围内提高脑内ＮＯ，对心血管活动有正性调节作用，降低脑内ＮＯ则对心血管活动有负性调节作用。
Rats were injected intracerebroventricular (icv) sodium nitroprusside (SNP), NO precursors L Arginine (Arg Arg Arg Arg Arg Arg), NO synthase (NOS) Inhibitor of NG nitro L arginine (NNLA), observed sober state of blood pressure and heart rate changes to explore the role of intracerebral NO to regulate cardiovascular activity in awake rats. Experimental results show that, icvSNP (8,16,32μg) to blood pressure, and a dose-response relationship, while heart rate. icvL Arg (200μg) or different doses of fine refined dipeptide also make blood pressure, heart rate; icvNNLA (100μg) is to make blood pressure, heart rate slows. The above results suggest that in a certain range to improve intracerebral NO, have a positive regulatory effect on cardiovascular activity, reduce the brain NO is negative regulation of cardiovascular activity.