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目的观察75岁以上心力衰竭患者氨基末端脑钠肽前体(NT-proBNP)与心功能的相关性。方法充血性心力衰竭患者280例为观察组与无心脏疾患者200例为对照组,采用心脏超声检测左室射血功能(LVEF),全自动免疫分析仪器检测NT-proBNP水平。结果观察组NT-proBNP水平显著高于对照组(P<0.05);对照组LVEF显著优于观察组(P<0.05)。随着NYHA分级逐渐升高,患者血清NT-proBNP逐渐升高(P<0.05)。LVEF、NYHA分级与NT-proBNP水平显著相关,而与性别则无相关性。结论 75岁以上心力衰竭患者NT-proBNP水平显著升高,且与心衰严重程度正相关,因此可作为诊断、评估预后及危险分层的重要指标。
Objective To investigate the relationship between NT-proBNP and cardiac function in patients with heart failure over 75 years of age. Methods 280 cases of congestive heart failure patients in the observation group and 200 cases without heart disease as the control group, the left ventricular ejection function (LVEF) was detected by echocardiography, NT-proBNP was detected by automatic immunoassay analyzer. Results The level of NT-proBNP in the observation group was significantly higher than that in the control group (P <0.05). The LVEF in the control group was significantly better than that in the observation group (P <0.05). With the gradual rise of NYHA classification, the serum NT-proBNP gradually increased (P <0.05). LVEF and NYHA classification were significantly correlated with NT-proBNP levels, but not with gender. Conclusion The NT-proBNP level in patients with heart failure over the age of 75 is significantly increased, and is positively correlated with the severity of heart failure. Therefore, it can be used as an important index in the diagnosis, prognosis and risk stratification.