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目的:考察大黄硝石汤对湿热黄疸大鼠模型的药效作用。方法:采用α-萘异硫氰酸酯(ANIT)诱导大鼠肝损伤与施加湿热环境复制中医湿热黄疸证候大鼠模型。预防性给予大黄硝石汤,通过检测给药后不同恢复期大鼠相关生理生化指标,对大黄硝石汤药效作用进行评价。结果:造模后24h、96h,与模型组相比,大黄硝石汤组(2.02g生药/kg)血清谷丙转氨酶、谷草转氨酶活性及血清总胆红素水平明显降低。大黄硝石汤亦可降低造模后引起的体温升高,改善异常的肝脾指数等。结论:大黄硝石汤能够降低湿热黄疸大鼠模型血清酶活性、血清总胆红素水平,降低肝脾指数比等,使异常的生理生化指标趋于正常,具有较好的保肝利胆退黄作用。
Objective: To investigate the pharmacodynamic effects of Danshuangxueshi Decoction on damp-heat jaundice in rats. Methods: Rat models of damp-heat jaundice syndrome were induced by using α-naphthalene isothiocyanate (ANIT) to induce liver injury and heat-damp environment in rats. Preventive administration of big yellow-brown stone soup, through the detection of different convalescent rats after administration of the relevant physiological and biochemical indicators of the efficacy of large yellow nitrate test. Results: Compared with the model group, the levels of AST, AST and total bilirubin in the Danshuang Xueshi Decoction group (2.02g crude drug / kg) were significantly decreased at 24h and 96h after modeling. Rhubarb nitrate stone soup can also reduce the temperature caused by modeling to improve the abnormal liver and spleen index. Conclusion: Dashenxitou Decoction can reduce the serum enzyme activity, serum total bilirubin level, reduce the ratio of liver and spleen index, so that the abnormal physiological and biochemical parameters tend to be normal, with good liver and gallbladder Huang effect.