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[目的]观察磷酸铝凝胶在溃疡性结肠炎治疗中的临床疗效。[方法]选择溃疡性结肠炎患者58例,随机分为磷酸铝凝胶治疗组(治疗组)30例及对照组28例。2组均口服美沙拉嗪片(3次/d,每次2片)的同时给予结肠保留灌肠治疗。对照组的灌肠液为0.9%氯化钠溶液30ml加入地塞米松5mg,治疗组在对照组的灌肠液中再添加磷酸铝凝胶;均1次/d,疗程2周。比较2组临床疗效。[结果]治疗后,治疗组完全缓解例数多于对照组,疾病活动指数低于对照组,腹泻、便血症状改善时间短于对照组,2组比较均差异有统计学意义(P<0.05)。[结论]磷酸铝凝胶联合美沙拉嗪片口服对溃疡性结肠炎的疗效显著。
[Objective] To observe the clinical efficacy of aluminum phosphate gel in the treatment of ulcerative colitis. [Methods] Fifty-eight patients with ulcerative colitis were selected and randomly divided into three groups: the aluminum phosphate gel treatment group (treatment group) and the control group (n = 28). Both groups were given Mesalazine tablets (3 times / d, each 2 tablets) while giving colon retention enema treatment. The control group enema was 0.9% sodium chloride solution 30ml dexamethasone 5mg, the treatment group in the control group enema was added aluminum phosphate gel; were 1 / d, treatment for 2 weeks. The clinical efficacy of two groups were compared. [Results] After treatment, the number of complete remission in the treatment group was more than that in the control group, and the index of disease activity was lower than that in the control group. The improvement time of diarrhea and blood in the stool was shorter than that of the control group. There was significant difference between the two groups (P <0.05) . [Conclusion] The effect of oral administration of aluminum phosphate gel and mesalazine tablets on ulcerative colitis is significant.