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本文报导AE_(121)破乳剂对小鼠的急性经口毒性和小鼠骨髓嗜多染红细胞微核试验。结果LD_(50)4875.86(4282.17～5551.41)mg/kg,小鼠骨髓微核试验,阳性对照明显高于空白对照组,各试验组与空白对照组比较,差异无显著性。实验结果表明AE_(121)破乳剂无明显致突变作用。
This paper reports the acute oral toxicity of AE_(121) demulsifier on mice and the micronucleus test of polychromatic erythrocytes of bone marrow in mice. Results LD_(50)4875.86 (4282.17～5551.451)mg/kg, micronucleus test of bone marrow in mice, positive control was significantly higher than the blank control group. There was no significant difference between the experimental group and the blank control group. The experimental results show that AE_(121) demulsifier has no obvious mutagenic effect.