患者男性,61岁,因肛周瘙痒伴溢液半年入院。体检:肛周见暗红色斑块状隆起,占据大半肛周,该处延伸至肛管外皮肤2～3cm,向肛内至齿状线。病理检查见肛周皮肤表皮内见灶状分布的印戒样细胞,考虑Paget病,后反复行结肠镜检查,未发现可疑病灶,患者行腹会阴联合直肠癌根治术,术后患者 Male patient, 61 years old, due to perianal pruritus with discharge six months admitted. Physical examination: the perianal see dark red plaque bulge, occupy most of the perianal, which extends to the external anal skin 2 ~ 3cm, to the anal line to the dentate. Pathological examination, see perianal skin epidermis see the focal distribution of signet-ring like cells, consider Paget disease, after repeated colonoscopy, found no suspicious lesions, the patient underwent abdominal perineal rectal cancer radical surgery, postoperative patients