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目的观察奈达铂联合氟尿嘧啶治疗晚期食管癌的疗效和毒性。方法奈达铂40mg/m2·d静脉滴入d1、d8天;氟尿嘧啶200mg/m2·d使用微量泵持续静脉滴注,连用2周。结果治疗组42例患者中,获CR3例,PR18例,总有效率(CR+PR)49.95%;对照组42例患者中CR2例,PR14例,总有效率38.1%。毒副反应以骨髓抑制为主,表现为白细胞和血小板减少,恶心呕吐,感觉性神经毒性,口腔粘膜炎,腹泻,手足综合症等。结论奈达铂联合氟尿嘧啶方案治疗晚期食管癌疗效显著,且毒副作用小,值得临床进一步研究。
Objective To observe the efficacy and toxicity of nedaplatin plus fluorouracil in the treatment of advanced esophageal cancer. Methods Nedaplatin 40mg / m2 · d intravenous d1, d8 days; fluorouracil 200mg / m2 · d continuous use of micro-pump intravenous infusion, once every 2 weeks. Results Among the 42 patients in the treatment group, CR3 and PR18 achieved a total effective rate (CR + PR) of 49.95%. Among the 42 patients in the control group, CR2 and PR14 achieved a total effective rate of 38.1%. Toxicity to bone marrow suppression, manifested as leukopenia and thrombocytopenia, nausea and vomiting, sensory neurotoxicity, oral mucositis, diarrhea, hand-foot syndrome and so on. Conclusion Nedaplatin combined with fluorouracil regimen has a significant curative effect on advanced esophageal cancer with less toxic and side effects and deserves clinical further study.