进行破损皮肤毒性试验,可提供某化学物质在短期内经皮肤途径可能对健康引起危害的资料,是研制皮肤用药所必需进行的1个试验项目,现将本实验室建立的1个较为简便、且结果重现性好的实验方法介绍如下: 动物及材料 动物 一般选用大鼠、家兔或豚鼠、除婴儿皮肤用药需用刚成年动物外,其余均用成年动物、大鼠体重200～300g;家 The test of the damaged skin toxicity can provide the information that a chemical substance may harm the health in the short term via the dermal route and is a pilot project necessary for the development of the dermal medication. The results reproducible experiments are described below: Animals and materials Animals generally use rats, rabbits or guinea pigs, in addition to infant skin medication just adult animals, the rest are used adult animals, rats weighing 200 ~ 300g;