目的:探讨上皮性卵巢癌肝脏转移更实用有效的治疗模式。方法:对2000~2010年在吉林省肿瘤医院首诊的21例卵巢癌肝转移病例分A组12例行全子宫双附件大网膜及阑尾切除术盆腔淋巴结清扫术联合TP方案序贯化疗,B组9例行全子宫双附件大网膜及阑尾切除术盆腔淋巴结清扫术同时行局部治疗(肝脏病灶切除术,或者肝脏射频消融,或者肝动脉介入治疗)联合TP方案全身化疗,对不同治疗方法生存率进行比较。结果:卵巢癌肝转移患者如有条件通过手术完整地切除肝脏肿瘤,完成完整的卵巢癌肿瘤细胞歼灭术,同时联合全身化疗是卵巢癌肝转移患者的首选治疗;无法手术切除肝脏转移肿瘤的患者局部射频消融或者肝动脉介入治疗联合全身化疗也有一定的优势。A组2年生存率22%,3年生存率为0;B组2年生存率77%,3年生存率44%,两组差异有统计学意义(P<0.01)。结论:肝脏射频消融或者肝动脉介入治疗要掌握适应证及治疗时机,否则加剧肿瘤进展。 Objective: To investigate the more practical and effective treatment modalities for liver metastasis of epithelial ovarian cancer. Methods: Twenty-one patients with liver metastasis of ovarian cancer who were first diagnosed in Cancer Hospital of Jilin Province from 2000 to 2010 were divided into group A (n = 12) and received double-attachment omentum and appendectomy combined with pelvic lymph node dissection combined with TP chemotherapy. In group B, 9 patients underwent hysterectomy and appendectomy, pelvic lymph node dissection and local chemotherapy (hepatectomy, or radiofrequency ablation of liver, or hepatic artery interventional therapy) combined with TP chemotherapy, Methods to compare the survival rate. Results: Patients with liver metastases of ovarian cancer who underwent surgery to completely remove the liver tumor and complete the complete ovarian cancer tumor cell annihilation surgery, combined with systemic chemotherapy is the preferred treatment for patients with liver metastasis of ovarian cancer; patients who can not be surgically removed liver metastases Local radiofrequency ablation or hepatic artery intervention combined with systemic chemotherapy also has some advantages. The 2-year survival rate was 22% in group A, and the 3-year survival rate was 0; the 2-year survival rate in group B was 77% and the 3-year survival rate was 44%. There was significant difference between the two groups (P <0.01). Conclusion: Radiofrequency ablation of liver or interventional treatment of hepatic artery should grasp indications and treatment timing, or exacerbate tumor progression.