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心力衰竭的代偿机理除心脏本身可通过各种方式使心输出量维持或接近正常,以满足组织代谢需要外,还有心脏以外其他组织器官的代偿,例如肾脏的代偿.在心外代偿中,神经内分泌的调节机理占有重要地位.近代认为,心力衰竭(简称心衰)激发的神经内分泌功能变化主要有两大类:一是交感神经—肾素血管紧张素-精氨酸加压素系统所致的外周血管收缩和水钠潴留的代偿机理;另一是前列腺素-心钠素所致的舒张血管和排钠利尿的调节机理。循环系统内环境稳定是这两种相互对抗机理作用的结果,此概念有利于了解心衰的发病机理,为心衰的治疗提供理论依据。
The compensatory mechanism of heart failure in addition to the heart itself can be maintained in various ways or close to normal cardiac output to meet the needs of tissue metabolism, there are other organs outside the heart of the compensatory, such as kidney compensation. Compensation, neuroendocrine regulatory mechanism occupies an important position.Modern thought, heart failure (referred to as heart failure) neuroendocrine function changes mainly in two categories: one is the sympathetic - renin angiotensin - arginine pressure Suprasec system caused by peripheral vasoconstriction and sodium and sodium compensatory mechanism; the other is prostaglandin - atrial natriuretic induced vasodilatation of blood vessels and diuretic regulation mechanism. The stable environment in the circulatory system is the result of the interaction between these two antagonistic mechanisms. This concept helps to understand the pathogenesis of heart failure and provides a theoretical basis for the treatment of heart failure.