癌转移,贯穿整个身体的肿瘤扩散,乃是一个有明显临床意义的变化过程。但有关其调控的分子生物学与细胞学机制,相对来说,我们几乎还不明瞭。扩散中的恶性肿瘤细胞能逃脱宿主防御体系的一种方式,现於本刊第301页报告提出:带有H-2基因的老鼠肉瘤细胞的转染系由这些细胞转移能力的丧失所调节。 Cancer metastasis, the spread of tumors throughout the body, is a process of significant clinical significance. However, relative to the molecular biology and cytological mechanisms of its regulation, we are relatively unclear. One way in which disseminated malignant cells can escape the host defense system is reported in the current report on page 301. The transfection of mouse sarcoma cells harboring the H-2 gene is regulated by the loss of the ability of these cells to metastasize.