溴隐亭(简称Br)和其他的麦角衍生物对大多数而不是所有的泌乳素瘤患者都能降低其血催乳素(PRL)达正常水平并恢复生育力。本研究描述Br治疗无效的PRL瘤病人的神经内分泌的特征。经手术取得某些病人的肿瘤细胞进行培养,以查明Br和其它神经激素对PRL释放的效力。为进一步分析这种降低反应的机理,作者比较了Br-敏感(对 Bromocriptine (Br) and other ergot derivatives reduce blood prolactin (PRL) levels and restore fertility in most, but not all patients with prolactinomas. This study describes the neuroendocrine characteristics of patients with refractory PRL treated with Br. Tumor cells from some patients were surgically cultivated to investigate the efficacy of Br and other neurohormones on PRL release. To further analyze this mechanism of lowering the response, the authors compared Br-sensitive (p