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目的探索梅毒患者血清TRUST转归的影响因素。方法对2011年4月—2014年6月深圳市南山区慢性病防治院首次确诊及治疗并随访24个月的277例梅毒患者进行调查,使用Cox比例风险回归模型分析梅毒患者血清TRUST转归的影响因素。结果不同性别、年龄、婚姻、文化程度和是否合并HIV感染的梅毒患者血清TRUST转阴情况之间差异均无统计学意义(P>0.05);不同诊断分期和初始TRUST滴度梅毒患者转阴情况之间差异均有统计学意义(P<0.05)。Cox比例风险回归模型分析结果显示:一期梅毒患者比隐性梅毒患者血清TRUST更易转阴(RR=3.04,95%CI:1.95~4.73;P<0.05),初始TRUST滴度≤1∶8患者比滴度>1∶8患者血清TRUST更易转阴(RR=2.34,95%CI:1.40~3.91;P<0.05)。结论梅毒的诊断分期和初始血清TRUST滴度是影响梅毒预后的独立影响因素。
Objective To explore the influencing factors of serum TRUST in syphilis patients. Methods A total of 277 syphilis patients diagnosed and treated in Nanshan District, Shenzhen for 24 months from April 2011 to June 2014 were investigated. Cox proportional hazards regression model was used to analyze the influence of serum TRUST on syphilis patients factor. Results There was no significant difference in the serum TRUST-negative prevalence between patients with syphilis and HIV infection (P> 0.05), with different gender, age, marital status, education level and degree of syphilis with or without HIV infection. The differences were statistically significant (P <0.05). Cox proportional hazards regression model analysis showed that the first-stage syphilis patients were more likely to be more negative than the serum levels of TRUST (RR = 3.04, 95% CI: 1.95 to 4.73; P <0.05), and those with initial TRUST titer less than or equal to 1: 8 TRUST was more likely to be negative than serum titer> 1: 8 (RR = 2.34, 95% CI: 1.40-3.91; P <0.05). Conclusion The diagnosis of syphilis and initial serum TRUST titer are independent prognostic factors of syphilis.