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以樟脑酸和氨乙基取代苯基硫脲为原料,合成了10个新型的樟脑酸基硫脲类化合物(5a-5j)。利用FT-IR、1H NMR、13C NMR、LC-MS和元素分析等手段对目标产物进行了结构表征。同时对化合物5a-5j的抑菌活性进行了测试。初步的生物活性测试表明,在质量浓度为50 mg/L时,大部分化合物具有一定的抑菌活性,其中化合物樟脑酸基邻甲氧基苯基硫脲5c(R=o-CH3O)和樟脑酸基间甲氧基苯基硫脲5d(R=m-CH3O)对番茄早疫病菌(Alternaria solani)的抑制率达86.9%,化合物樟脑酸基间甲氧基苯基硫脲5d、樟脑酸基间甲基苯基硫脲5g(R=m-CH3)和樟脑酸基对溴苯基硫脲5i(R=p-Br)对苹果轮纹病菌(Physalospora piricola)的抑制率达86.1%。此外,化合物5i还对花生褐斑病毒(Cercospora arachidicola)具有最好的抑制率(73.6%)。
Ten camphoric acid thioureas (5a-5j) were synthesized from camphoric acid and aminoethyl-substituted phenylthioureas. The structure of the target product was characterized by FT-IR, 1H NMR, 13C NMR, LC-MS and elemental analysis. The antibacterial activities of compounds 5a-5j were also tested. The preliminary bioassay showed that most of the compounds had some antibacterial activity at the concentration of 50 mg / L. Among them, the compounds 5c (R = o-CH3O) and camphor The inhibition rate of acid-based methoxyphenylthiourea 5d (R = m-CH3O) to Alternaria solani was 86.9%, the compound camphorate methyoxy phenyl thiourea 5d, camphor acid The inhibitory rate of 5g (R = m-CH3) and 5n (R = p-Br) of camphoylmethylphenyl bromothiourea to Physalospora piricola was 86.1%. In addition, compound 5i also had the best inhibitory rate (73.6%) against Cercospora arachidicola.