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目的分析子痫前期患者血清软骨糖蛋白40(YKL-40)、趋化因子配体10(CXCL10)水平,探讨子痫前期的发生与炎症反应及免疫反应关系。方法选取子痫前期患者45例,其中重度子痫前期25例(A组),轻度子痫前期20例(B组);对照组为正常妊娠孕妇40例(C组)和正常未孕妇女40例(D组)。用ELISA法检测血清YKL-40和CXCL10水平。结果 A、B、C、D组血清YKL-40分别为(10475.50±4444.42)pg/ml、(6446.14±1902.11)pg/ml、(1301.67±347.24)pg/ml、(1087.98±420.39)pg/ml;CXCL10分别为(147.30±14.52)pg/ml、(136.62±16.20)pg/ml、(96.20±9.42)pg/ml、(81.10±8.24)pg/ml;A、B、C组YKL-40、CXCL10的表达高于D组(P<0.05),A、B组增高更为明显,差异有统计学意义(P<0.05)。结论子痫前期患者YKL-40和CXCL10增高;YKL-40与子痫前期的严重性相关。
Objective To analyze the serum level of cartilage glycoprotein 40 (YKL-40) and chemokine ligand 10 (CXCL10) in patients with preeclampsia and to explore the relationship between the occurrence of preeclampsia and inflammatory reaction and immune response. Methods Forty - five patients with preeclampsia were selected, including 25 cases of severe preeclampsia (group A) and 20 cases of mild preeclampsia (group B). The control group consisted of 40 pregnant women with normal pregnancy (group C) and normal pregnant women 40 cases (D group). Serum levels of YKL-40 and CXCL10 were measured by ELISA. Results The serum levels of YKL-40 in group A, B, C and D were (10475.50 ± 4444.42) pg / ml, (6446.14 ± 1902.11) pg / ml, (1301.67 ± 347.24) pg / ml and (1087.98 ± 420.39) pg / (147.30 ± 14.52) pg / ml, (136.62 ± 16.20) pg / ml, 96.20 ± 9.42 pg / ml and 81.10 ± 8.24 pg / ml for CXCL10, The expression of CXCL10 was higher in group D than in group D (P <0.05), while the level of CXCL10 was more obvious in group A and B (P <0.05). Conclusions Patients with preeclampsia have elevated YKL-40 and CXCL10, while YKL-40 is associated with the severity of preeclampsia.