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在急性心肌梗塞并发完全性房室传导阻滞病人可,关干利多卡因对房室连接区逸搏频率的影响尚未见报道;本文首次报告其研究结果,以利进一步了解该药抗心律失常的作用机制。方法:将10例完全性房室传导阻滞病人分为两组:组Ⅰ、7例非急性心肌梗塞,组Ⅱ、3例患有急性前蹙心肌梗塞。10例患者,均无心力衰竭、低血压或电解质紊乱,亦未接受其他抗心律失常药。用药前记录希氏束电图,全部病例置双极导管于右室顶端,连接起搏器,并将其频率控制于20次/分。然后,在2分钟内静注利多卡因1.5毫克/公斤,继以3毫克/分的速度滴注10分钟。用药前后记录心电图,并对照R-R与P-P间期。结果:用药前所有患者均为窦性心律。9例希
In patients with acute myocardial infarction complicated with atrioventricular block, the effect of lidocaine on the escape frequency of atrioventricular junctional region has not been reported; this article reports its findings for the first time in order to provide a better understanding of the antiarrhythmic The mechanism of action. Methods: Ten patients with complete atrioventricular block were divided into two groups: group Ⅰ, 7 non-acute myocardial infarction, group Ⅱ, 3 patients with acute anterior myocardial infarction. None of the 10 patients had heart failure, hypotension or electrolyte disturbances and did not receive other antiarrhythmic drugs. Before treatment record His bundle, all cases set bipolar catheter in the right ventricular top, connected pacemaker, and its frequency control at 20 beats / min. Then, lidocaine 1.5 mg / kg was intravenously administered within 2 minutes, followed by instillation at a rate of 3 mg / min for 10 minutes. Before and after recording ECG, and control R-R and P-P interval. Results: All patients were sinus rhythm before treatment. 9 cases of hope