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目的：研究川天康胶囊对血小板功能的影响与评价其临床用药安全性。方法：以血小板聚集功能测定法（比值法）测定血小板聚集率，以剪尾法、玻璃毛细管法分别测定出、凝血时间；以急性毒性试验法（最大耐受量测定法）及长期毒性试验法分别进行安全限度试验及观察规定时间内连续给药所产生的反应。结果：本品能明显降低老年大鼠血小板的聚集率；显著延长小鼠的出、凝血时间；小鼠ｉｇ最大耐受量为临床１日用量的５００倍；大鼠ｉｇ９周，多指标观察未见明显毒性反应。结论：提示本品对实验动物具有明显血小板解聚作用，能显著地抑制血小板的聚集功能，毒性很小，临床服用安全
Objective: To study the effect of Chuantiankang capsule on platelet function and evaluate its clinical safety. METHODS: Platelet aggregation assay (ratio method) was used to determine the platelet aggregation rate. The cut-tailing method and glass capillary method were used to determine the clotting time, and the acute toxicity test (maximum tolerated dose assay) and long-term toxicity test were used. The safety limits were tested separately and the response to continuous administration over a specified period of time was observed. Results: The product can significantly reduce the aggregation rate of platelets in aged rats; significantly prolong the time of the mice’s outflow and coagulation; the maximal tolerance of mice is 500 times of the daily dosage; the rats are ig 9 weeks, and multiple indicators are not observed. See obvious toxicity. Conclusion: This product has obvious platelet depolymerization effect on experimental animals, can significantly inhibit the aggregation of platelets, the toxicity is very small, clinical safety