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目的:观察归莲活血解毒方治疗胃癌前病变的临床疗效。方法:采用随机数字表法将69例胃癌前病变患者分为治疗组35例和对照组34例,治疗组予以归莲活血解毒方治疗,对照组予以胃复春治疗。观察治疗前后的临床症状变化,并检测空腹静脉血血浆内皮素(ET)、降钙素基因相关肽(CGRP)含量的变化。结果:治疗组总有效率为82.9%,对照组为64.7%,2组比较,差异有显著性意义(P<0.05)。治疗后2组临床症状积分均显著下降,与治疗前比较,差异均有非常显著性意义(P<0.01)。胃痛、胃及两胁胀满、大便干燥症状2组间比较,差异有显著性意义(P<0.05)。治疗后治疗组ET显著降低,CGRP明显升高,而对照组变化不明显,2组比较,差异均有显著性意义(P<0.05)。结论:归莲活血解毒方可改善胃黏膜血流量,促进腺体恢复。
Objective: To observe the clinical curative effect of Guilian Huoxue Jiedu Fang on gastric precancerous lesions. Methods: A total of 69 patients with gastric precancerous lesions were divided into treatment group (35 cases) and control group (34 cases) by random number table method. The treatment group was treated with Gundian Huoxue Jiedu Decoction and the control group with Weifuchun. The changes of clinical symptoms before and after treatment were observed. The changes of plasma endothelin (ET) and calcitonin gene related peptide (CGRP) in fasting venous blood were detected. Results: The total effective rate was 82.9% in the treatment group and 64.7% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the score of clinical symptoms in both groups decreased significantly, with significant difference compared with before treatment (P <0.01). Stomach pain, stomach and two threatening fullness, dry stool symptoms between the two groups, the difference was significant (P <0.05). After treatment, the treatment group ET decreased significantly, CGRP increased significantly, while the control group did not change significantly in the two groups, the difference was significant (P <0.05). Conclusion: Guilian Huoxuehuoxue can improve gastric mucosal blood flow and promote gland recovery.