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目的研究阿苯达唑治疗肝吸虫病前后患者血清细胞因子TNF鄄α、IL鄄6和IL鄄8水平的变化情况,探讨其在肝吸虫致病机制中的作用及临床意义。方法以健康人作对照,健康人和肝吸虫病患者在口服阿苯达唑治疗前、后4周分别于清晨空腹采集静脉血,用ELISA方法检测患者血清TNF鄄α、IL鄄6和IL鄄8水平。结果治疗前肝吸虫病患者血清TNF鄄α、IL鄄6和IL鄄8水平升高,与健康对照组比较有统计学意义。口服阿苯达唑治疗后,患者血清TNF鄄α、IL鄄6和IL鄄8水平下降,与治疗前比较有统计学意义。结论肝吸虫病患者血清细胞因子水平异常,免疫功能下降,应用阿苯达唑治疗后免疫抑制得到改善;阿苯达唑对于治疗肝吸虫病具有较好的疗效。
Objective To study the changes of serum cytokines TNF-α, IL-6 and IL-8 levels before and after treatment with albendazole and to explore its role in the pathogenesis of hepatic flukes and its clinical significance. Methods Healthy volunteers and patients with hepatic dendritic diseases were given fasting morning fasting blood samples before and 4 weeks after oral administration of albendazole. Serum levels of TNF-α, IL-6 and IL-6 were measured by ELISA 8 levels. Results Serum levels of TNF-α, IL-6 and IL-8 in patients with hepatic trematodes before treatment were significantly higher than those in healthy controls. After oral albendazole treatment, serum TNF-α, IL-6 and IL-8 levels decreased, compared with before treatment was statistically significant. Conclusions Serum levels of cytokines in patients with hepatic dendritic diseases are abnormal and the immune function is decreased. The immunosuppression is improved after the application of albendazole. Albendazole has a good curative effect on the treatment of.